XPCS nanoparticle dynamics in gastrointestinal fluids
Apr 2026
Three days of beamtime were conducted at Sirius to investigate the behavior of silica nanoparticles, used as model systems, under conditions mimicking their passage through gastrointestinal fluids. The experiments were designed to capture the dynamic response of the nanoparticle system as a function of the surrounding medium, with particular emphasis on changes in mobility and interaction states.
X-ray Photon Correlation Spectroscopy (XPCS) was employed to probe nanoscale dynamics in situ, providing access to time-dependent fluctuations associated with diffusion and collective behavior. In parallel, Small-Angle X-ray Scattering (SAXS) measurements were performed under the same conditions to characterize the nanoparticles' structural state. The SAXS data were used to support and contextualize the dynamic information obtained from XPCS, ensuring consistency between structural and dynamical interpretations of the system.
First Beamtime of the Year at the Cateretê Beamline (Sirius)
Fev 2026
The first beamtime of the year was successfully completed at the Cateretê beamline at Sirius (CNPEM, Brazil). The campaign focused on investigating the cellular internalization of polystyrene nanoparticles coated with environmental pollutants, aiming to understand how surface chemistry modulates nanoparticle–cell interactions in biologically relevant systems. The primary objective was methodological: to refine and standardize cell preparation protocols to ensure reproducibility, structural preservation, and compatibility with high-resolution synchrotron imaging. As workflows advance toward increasingly correlative approaches, optimizing upstream biological preparation becomes as critical as the imaging itself, ensuring that datasets accurately reflect intracellular organization. Beyond data acquisition, the long-term goal is to establish a robust and scalable experimental pipeline aligned with ongoing developments within the Sirius ecosystem. This first beamtime represents an important step in consolidating that workflow and preparing for the upcoming experimental sessions scheduled in the near future.
Mateus Cardoso Invited to Speak at Two International Conferences
Jan 2026
Mateus Cardoso has been invited to participate in two major international scientific conferences in 2026, further highlighting the international recognition of his research in synchrotron-based techniques and nano–bio interfaces. He will speak at Coherence 2026, to be held in Madison, Wisconsin (USA). The Coherence conference is a leading international forum dedicated to advances in coherent X-ray science, bringing together experts in synchrotron radiation, X-ray photon correlation spectroscopy (XPCS), coherent diffraction imaging (CDI), and related methodologies. His participation reflects ongoing contributions to the development and application of advanced synchrotron-based approaches to probe nanoscale structure and dynamics. In addition, Mateus Cardoso has been invited to present at the XRM 2026 (International Conference on X-Ray Microscopy), to be held in Campinas, Brazil. XRM is one of the most important global meetings in the field of X-ray microscopy and imaging, bringing together researchers at the forefront of nanoscale characterization, multimodal imaging, and in situ/in operando studies.